Clinical Studies of the Influence of Anticoagulants on the Resin Sponge Uptake of I131Triiodothyronine

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Abstract
The effects of anticoagulants in vivo and in vitro on the resin sponge uptake of I131 triiodothyronine (T-3) were investigated with duplicate determinations in 65 euthyroid controls and 29 patients receiving oral warfarin sodium. A mean value of 30.09% [plus or minus] 2.49% for ethylenediaminetetra-acetate plasma correlated closely with serum values of 29.64 [plus or minus] 2.52% (r=0.75) and heparinized plasma values of 31.64% [plus or minus] 2.44% (r=0.77). Analysis of T-3 resin uptake results in patients receiving oral anticoagulants revealcd consistently normal values in 65%, whereas unexplainably high or low values were recorded in 27.6%. Consistently, abnormal results were recorded in only 1 patient who had serial determinations; in the remainder of this group values were distributed in a random fashion between normal, increased, and decreased resin upta uptakes during the course of treatment. Euthyroid patients receiving warfarin as an anticoagulant can frequently be expected to have normal uptake values, but intermittently abnormal results may be observed in a significant number.

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