Renal Responses to Exercise, Heat and Dehydration

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Abstract
Renal plasma flow and glomerular filtration rate were studied in 6 normal men during rest and prolonged moderate exercise (a) in a cool environment, (b) in a hot environment and (c) when dehydrated by 4-8% of the body wt. in a hot environment. Dehydration in the heat reduced the avg. glomerular filtration rate by 12% below controls in the resting men. Avg. decreases of 19 and 51% from the control level of glomerular filtration rate were observed respectively during exercise in the heat and during exercise in the heat with dehydration. Exercise reduced renal plasma flow by an avg. of 22% in the cool environment, 31% in the heat and 56% when the men were dehydrated in the heat. The filtration fraction increased from rest to exercise in all expts. When water re-absorption was maximal in dehydration, there was a linear relationship between urine flow and glomerular filtration rate.

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