Combined Hemophilia and Christmas Disease

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Abstract
A case of combined hemophilia (AHG deficiency) and Christmas disease is described. Five other members of the family had either hemophilia or Christmas disease. The manner of inheritance of the two disorders was uncertain but it was considered most probable that in the mother of the combined case, coupling of the two genes had resulted from a cross-over involving the X-chromosome. It is believed that the findings are consistent with the view that the hemophilia and Christmas disease genes have quite separate loci on the X-chromosome.