THE ACTION OF GLUCAGON-INSULIN MIXTURES IN DIABETIC PATIENTS*

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Abstract
Studies on the action of glucagon-insulin mixtures in 30 unselected hospitalized diabetic patients are presented. The findings indicate that glucagon and insulin combined increase glucose uptake in the forearm significantly more than does insulin alone. This effect appears to be independent of the severity of the diabetes but is more pronounced when the fasting arterial glucose concentration is greater than 120 mg. per 100 ml. Analysis of the response of arterial glucose levels to the glucagon-insulin mixtures revealed that fasting blood glucose levels and the ratio of glucagon to insulin in the mixture are important factors in this response. Arterial glucose levels were consistently stabilized when the fasting level was greater than 170 mg. per 100 ml. and the ratio of glucagon to insulin in the mixture was 0.26 to 0.90. Possible applications of these findings to the treatment of diabetic patients are suggested.

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