Effect of Serine Hydroxamate and Methyl a-D-glucopyranoside Treatment on Nucleoside Polyphosphate Pools, RNA and Protein Accumulation in Streptomyces hygroscopicus
- 1 October 1984
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 130 (10) , 2549-2558
- https://doi.org/10.1099/00221287-130-10-2549
Abstract
SUMMARY: The accumulation of RNA and protein and the kinetics of nucleoside triphosphate and guanosine polyphosphate pools during amino acid starvation and carbon source downshift were investigated in Streptomyces hygroscopicus. RNA accumulation was controlled stringently during both amino acid starvation and carbon source downshift. The pool size of ppGpp increased dramatically under these conditions. However, the intracellular concentrations of nucleoside triphosphates were low and the concentration of guanosine polyphosphates was much lower than in Escherichia coli. The possible significance of this phenomenon in the regulation is discussed.This publication has 18 references indexed in Scilit:
- Accumulation of ppGpp in a relA mutant of Escherichia coli during amino acid starvation.Journal of Biological Chemistry, 1980
- Occurrence of Guanosine-5′-diphosphate-3′-diphosphate and Adenosine-5′-triphosphate-3′-diphosphate inStreptomyces galilaeusAgricultural and Biological Chemistry, 1980
- Metabolic regulation in tylosin-producing Streptomyces fradiae: regulatory role of adenylate nucleotide pool and enzymes involved in biosynthesis of tylonolide precursorsAntimicrobial Agents and Chemotherapy, 1980
- A new nucleotide involved in the stringent response in Escherichia coli. Guanosine 5‘-diphosphate-3‘-monophosphate.Journal of Biological Chemistry, 1979
- The synthesis of highly phosphorylated nucleotides, RNA and protein by Streptomyces aureofaciens.The Journal of Antibiotics, 1979
- Intracellular levels of guanosine 5′-diphosphate 3′-diphosphate (ppGpp) and guanosine 5′-triphosphate 3′-diphosphate (pppGpp) in cultures of Streptomyces griseus producing streptomycinCanadian Journal of Microbiology, 1978
- Elongation of rod-shaped bacteriaJournal of Theoretical Biology, 1977
- ppGpp cycle in Escherichia coliMolecular Genetics and Genomics, 1977
- Regulation and biosynthesis of secondary metabolitesFolia Microbiologica, 1976
- Control of RNA synthesis in Escherichia coliJournal of Molecular Biology, 1968