INDUCTION OF LEUKOCHEMOTAXIS BY PEPTIDOGLYCAN OF STAPHYLOCOCCUS AUREUS

1 September 1978

journal article
research article
Published by Wiley in Acta Pathologica Microbiologica Scandinavica Section B Microbiology

Vol. 86B (1-6) , 375-378
https://doi.org/10.1111/j.1699-0463.1978.tb00059.x

Abstract

Leukochemotactic activity of staphylococcal peptidoglycan and isolated, specified fragments has been studied. The D-Ala-D-Ala group of the pentapeptide was found to be the major cytotaxigen, and C5a to be the dominant cytotaxin. A molecular weight of about 2,000 appeared to be a critical lower limit for inducing chemotactic response, the highest effect being observed with a fragment having a molecular weight of 3,000. The effect seems to depend on the kind of available antigenic determinants in the fragments and the proportion of specific antibodies in the complement source.

Keywords

This publication has 4 references indexed in Scilit:

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