Teratogenic Action in Rats of Reserpine Alone and in Combination with Salicylate and Immobilization.

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Abstract
Summary Large doses of reserpine administered to pregnant rats on the ninth or tenth days of gestation are highly teratogenic. Pre-treatment with reserpine significantly increases salicylate teratogenicity and augments the effect of immobilization on salicylate teratogenicity. A low, but significant teratogenicity also results from epinephrine administration on the tenth day. The types of anomaly produced by all these agents arc similar except that reserpine or epinephrine also produce the anomaly of stunted fetuses lacking most of the axial skeleton. These findings suggest that disturbed catecholamine metabolism may be an important teratogenic factor.