1978 COLLEGE-OF-AMERICAN-PATHOLOGISTS SURVEY OF ANALYSES OF 5 SERUM ENZYMES BY 450 LABORATORIES
- 1 January 1979
- journal article
- research article
- Vol. 72 (2) , 285-298
Abstract
Sets of survey specimens with known linear interrelationships were analyzed on 4 occasions by .apprx. 450 laboratories for the 5 enzymes lactate dehydrogenase, Asp aminotransferase, creatine kinase, Ala aminotransferase and alkaline phosphatase. The results are summarized in terms of the apparent precision and relative accuracy of various analytical systems, and some apparent problems in enzyme assays are identified. The results show that interlaboratory differences in enzyme analyses are not primarily due to differences in the way laboratorians utilize their analytical systems, but rather are due to fundamental differences in the instruments and reagents supplied to the laboratorians. The attainment of interlaboratory comparability of enzyme analyses is a problem that can best be addressed by the manufacturers of instruments and reagents, rather than by individual laboratorians.This publication has 4 references indexed in Scilit:
- 1977 COLLEGE OF AMERICAN PATHOLOGISTS ENZYMOLOGY SURVEY - PRINCIPAL FINDINGS1978
- Design of quality-control specimens for use with a small multi-channel analyzer.Clinical Chemistry, 1977
- INTERLABORATORY SURVEY OF ENZYMATIC ANALYSES .2. INTERMEDIATE STUDIES1977
- INTERLABORATORY SURVEY OF ENZYME ANALYSES .1. PRELIMINARY STUDIES1976