Phorbol ester modulates serotonin receptor‐mediated increases in inositol phosphate production and calcium mobilization in cultured rat vascular smooth muscle cells
Open Access
- 4 July 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 234 (1) , 228-230
- https://doi.org/10.1016/0014-5793(88)81340-1
Abstract
The effect of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) on serotonin‐induced inositol phosphate (IP) accumulation and intracellular free Ca2+ concentrations ([Ca2+]i) was investigated in cultured rat vascular smooth muscle cells. Pretreatment with TPA had no effect on basal levels of both IP production and [Ca2+]i, whereas it significantly attenuated serotonin‐induced increases in both IP production and [Ca2+]i. These data suggest that protein kinase C is involved in the negative feedback control of serotonin‐induced rises in both IP production and [Ca2+]i.Keywords
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