Serum Gastrin after 12 Months' Continuous Cimetidine Therapy for Duodenal Ulcer

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Abstract
Serum immunoreactive gastrin [GS] was measured in 14 patients with duodenal ulcer before and during a 12-mo. course of cimetidine [CM] 400 mg 2.times./day. All patients were symptomatically well during the CM therapy and both basal GS and that in response to a protein rich meal were assessed before, at 6 mo. and at 12 mo. during therapy. The basal and post-prandial GS were significantly higher at 6 and 12 mo. on CM than before CM but the 6 and 12 mo. levels were similar. The progressive increase in serum GS during 6 mo. of continuous CM therapy does not occur beyond this time period.