AMINOACIDURIA IN RATS AFTER TREATMENT WITH THE ETHYL ESTER OF GAMMA-BUTYROBETAINE

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Abstract
Previous workers have shown that the urine of patients with muscular dystrophy contains excessive amounts of amino acids. Using paper chromatographic analysis, these workers found that the amino acid methylhistidine is among those excreted in large amounts. Rats do not normally excrete methylhistidine, but in our experiments it was found that intramuscular injection of the ethyl ester of gamma-butyrobetaine into rats caused both the excretion of methylhistidine and an excessive aminoaciduria, presumably through the breakdown of muscle proteins.