Eine neue Funktion des nicht-pigmentierten Epithels der Ziliarkörperfortsätze bei der Kammerwasserproduktion

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Abstract
The invagination of the optic vesicle has, as one of its consequences, the apposition of the apices of the nonpigmented and pigmented epithelia of the ciliary processes of the eye. There are well developed intercellular ciliary channels formed at the apices of these cells. Embryologically the ciliary epithelia are homologous to the epithelia of the choroid plexus, a characteristically differentiated ependyma. These epithelial cells have a polarity. For example, the supranuclear region of the nonpigmented epithelia has Golgi apparatus. While stimulation of the epithelia of the choroid plexus by beta adrenergics or cholera toxin increases the rate of production of cerebrospinal fluid, similar stimulation of the adenylate complex within the ciliary epithelia decreases aqueous human production. When the secretory function of the nonpigmented epithelial cell is activated, fluid is probably reaborbed from the posterior chamber and secreted apically into the intercellular ciliary channels, in accord with cell polarity, thereby reducing net aqueous inflow. The fluid may enter the ciliary stroma thereafter, and thus, may become part of what may be called uveal scleral flow, or in this instance, uveal flow. The anatomy, physiology and chemistry fit this hypothesis and form the basis for new investigations of a 2-way transport across the ciliary epithelia.