Uninfected cell polymerase efficiently transcribes early but not late herpes simplex virus type 1 mRNA.
- 1 October 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (10) , 6139-6143
- https://doi.org/10.1073/pnas.78.10.6139
Abstract
The sequences of the DNA encoding the 5'' ends of 1 early and 1 late herpes simplex virus type 1 mRNA were analyzed and the 5'' ends of these mRNA species were precisely located. Neither mRNA species is spliced and the noncoding strand of the DNA contains recognizable T-A-T-A and C-A-T boxes upstream from their respective 5'' ends. The early mRNA was efficiently transcribed by a commercially available uninfected [human cervical carcinoma HeLa] cell lysate system, but the late mRNA was not. This difference between early and late mRNA appears to be general in this virus.This publication has 28 references indexed in Scilit:
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