Analysis of the Relationships of the Ploidy and Cell Cycle Kinetics to Differentiation and the Female Sex Steroid Hormone Receptors in Adenocarcinoma of the Endometrium
Open Access
- 1 May 1986
- journal article
- research article
- Published by Oxford University Press (OUP) in American Journal of Clinical Pathology
- Vol. 85 (5) , 536-541
- https://doi.org/10.1093/ajcp/85.5.536
Abstract
Flow cytometry was used to evaluate proliferative activity and ploidy status in 21 endometrial adenocarcinomas. These data were compared with their histologic and nuclear grades and their estrogen and progesterone receptor contents. Proliferative activity was significantly related to histologic and nuclear grades and the progesterone receptor status but not to the estrogen receptor status. Unlike the majority of solid human malignant neoplasms, only seven tumors were aneuploid, the remainder being diploid. Ploidy was not significantly associated with either grading system, receptor status, or the proliferative index.Keywords
This publication has 26 references indexed in Scilit:
- Improvements in steroid receptor assays including rapid computer analysis of dataAnalytical Biochemistry, 1980
- Female sex steroid receptors in normal, hyperplastic and carcinomatous endometrium. The relationship to serum steroid hormones and gonadotropins and changes during medroxyprogesterone acetate administrationInternational Journal of Cancer, 1979
- Estradiol and progesterone receptors in normal and neoplastic endometrium: Correlations between receptors, histopathological examinations and clinical responses under progestin therapyInternational Journal of Cancer, 1979
- Progesterone binding by human endometrial tissue during the proliferative and secretory phases of the menstrual cycle and by hyperplastic and carcinomatous endometriumAmerican Journal of Obstetrics and Gynecology, 1979
- CORRELATION OF ESTROGEN AND PROGESTERONE RECEPTORS WITH HISTOLOGIC DIFFERENTIATION IN ENDOMETRIAL ADENOCARCINOMA1979
- Hormone Serum Levels and Hormone Receptor Contents of Endometria in Women with Normal Menstrual Cycles and Patients Bearing Endometrial CarcinomaGynecologic and Obstetric Investigation, 1979
- CELL-PROLIFERATION KINETICS IN GYNECOLOGIC CANCER1977
- Prognostic Significance of Ploidy Level in Human Tumors. I. Carcinoma of the Uterus2JNCI Journal of the National Cancer Institute, 1976
- MORPHOLOGY AND DNA CONTENT OF ENDOMETRIAL CANCER NUCLEI UNDER PROGESTOGEN TREATMENT1976
- Deoxyribonucleic acid content of presumed precursors of endometrial carcinomaCancer, 1967