THE EFFECT OF A STRESS UPON THE GLYCOSURIA OF PARTIALLY DEPANCREATIZED FORCE-FED RATS

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Abstract
Partially depancreatized male rats were force-fed a fluid diet. The subcut. injn. of solns. of 1.5% formaldehyde in doses of 0.25, 0.5, and 1 cc. twice daily for 7 days, 5 rats per dose level, caused some decrease in the level of urinary glucose in mildly diabetic rats. When the injns. were stopped, the glycosuria was re-established at its pre-injn. level. The admn. of similar amts. of formaldehyde to 5 severely diabetic rats did not affect the level of glycosuria. Five moderately diabetic rats were given 0.25 cc. of 1.5% formaldehyde soln. twice daily for 28 days. There was a decrease in the level of urinary glucose in each animal which persisted for the duration of the injns. These data do not support the hypothesis that activation of the adrenal cortices during stress causes exacerbation of diabetes.
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