The Measure of Erythropoiesis in Anemias I. The Mixing Time and the Immediate Post-Transfusion Disappearance of T-1824 Dye and of Cr51-Tagged Erythrocytes in Relation to Blood Volume Determination

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Abstract
The mixing time of transfused red blood cells which had been exposed to Cr51, and of injected dye T-1824 occur within 2 minutes of each other, but vary with each individual. In most normal individuals the maximum concentration of the dye occurs between 2-3 minutes after injection, declining after this. For the measurement of blood volume with the dye, the highest concentration of several specimens is chosen. For the Cr51-tagged cells, the initial 100% radioactivity is obtained from an average of all values, from mixing time to 10 minutes post-transfusion.