Macrophage Restriction of Marek's Disease Virus Replication and Lymphoma Cell Proliferation
Open Access
- 1 September 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 123 (3) , 1088-1091
- https://doi.org/10.4049/jimmunol.123.3.1088
Abstract
Macrophages are shown to restrict the replication of Marek's disease virus (MDV) and isotope uptake by spleen cells from chickens bearing Marek's disease (MD) tumors. The titer of virus from duck embryo fibroblasts (DEF) co-cultivation with MDV-spleen cells pretreated to deplete marcophages was 4- to 18-fold higher than with untreated cells. Treated MDV-spleen cells increased isotope uptake by 2-fold. These restrictive activities are attributable to macrophage regulation of cell proliferation.This publication has 5 references indexed in Scilit:
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- Cell-Mediated Cytotoxic Response to Cells Bearing Marek's Disease Tumor-Associated Surface Antigen in Chickens Infected With Marek's Disease VirusJNCI Journal of the National Cancer Institute, 1977
- Expression of Virus-specific, Thymus-specific and Tumour-specific Antigens in Lymphoblastoid Cell Lines Derived from Marek's Disease LymphomasJournal of General Virology, 1977
- Macrophage regulation of mitogen-induced blastogenesisCellular Immunology, 1977
- Agent of Marek's Disease in Tissue CultureNature, 1967