Decreased Brain Dopamine Synthesis Rate and Increased [3H]Spiroperidol Binding in Streptozotocin‐Diabetic Rats
- 1 May 1983
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 40 (5) , 1456-1459
- https://doi.org/10.1111/j.1471-4159.1983.tb13590.x
Abstract
The rate of accumulation of 3,4-dihydroxyphenylalanine following decarboxylase inhibition and of homovanillic acid following probenecid treatment were significantly decreased in streptozotocin-diabetic rats. These changes were observed in both the striatum and limbic forebrain. The Bmax for [3H]spiroperidol receptor binding was significantly increased in both brain regions. All of these neurochemical changes were reversed by insulin replacement therapy. Whether these neurochemical changes are attributable to chronic hyperglycemia or some other aspect of the diabetic state is not known.Keywords
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