Induction and Potentiation of Phagocyte-Mediated Tumor Lysis by Chemotherapeutic Drugs for Cancer

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Abstract
Some selected anti-cancer drugs evidently induce tumor lysis in vitro in cooperation with phagocytic cells (drug-dependent cellular cytotoxicity; DDCC) and chemotherapeutic drugs augment the mediator-dependent killing activity of macrophages. Tumor cells pretreated with the drugs [actinomycin D, adriamycin, mitomycin C, bleomycin and vincristine] were susceptible to phagocyte-mediated killing. Tumor necrosis serum can also cooperate with some drugs in killing tumor cells. Some selected drugs can induce cytotoxic macrophages and the quantitative changes of phagocytes such as polymorphonuclear leukocytes. Some anti-cancer drugs apparently have the activities of inactivation of tumor cells and/or activation of host cells. Tumor cells may be killed effectively in vivo by anti-cancer drugs through these mechanisms. [Mice were used.].