EXCRETION DES STEROIDES CHEZ DES FEMMES PRESENTANT UN VIRILISME PILAIRE ASSOCIE A DES TROUBLES DU CYCLE MENSTRUEL

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Abstract
The authors present 39 observations of hirsutism or hairy virilism associated with important disturbances of the menstrual cycle and in whom they find no abnormality of the steroid secretion of adrenocortical origin. The observations included 20 cases of amenor-rhoea and 19 cases of spaniomenorrhoea or hypomenorrhoea with ovular cycle. After administration of 15 mg of dexamethasone or 9a-fluoro-16a-methylprednisolone in five consecutive days, they have ascertained the existence of an appreciable amount of residual 17-ketosteroids. These values were significantly increased, as compared with those found in normal women who presented a hairy virilism of adrenocortical origin with normal or moderately increased values of 17-ketosteroids. Moreover, most of these subjects showed an abnormal increase of the phenolsteroids, related most often to the estriol fraction. The authors deem that these abnormalities of the excretion of the residual 17-ketosteroids and phenolsteroids after suppression of corticotrophin activity by dexamethasone is characteristic of the ovarian origin of the hairy virilism.