Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection
- 20 December 2005
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 38 (1) , 38-46
- https://doi.org/10.1038/ng1698
Abstract
Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection.Keywords
This publication has 38 references indexed in Scilit:
- Association of Human‐Leukocyte‐Antigen Class I (B*0703) and Class II (DRB1*0301) Genotypes with Susceptibility and Resistance to the Development of Severe Acute Respiratory SyndromeThe Journal of Infectious Diseases, 2004
- Evaluation and Validation of an Enzyme-Linked Immunosorbent Assay and an Immunochromatographic Test for Serological Diagnosis of Severe Acute Respiratory SyndromeClinical and Vaccine Immunology, 2004
- pH-Dependent Entry of Severe Acute Respiratory Syndrome Coronavirus Is Mediated by the Spike Glycoprotein and Enhanced by Dendritic Cell Transfer through DC-SIGNJournal of Virology, 2004
- Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug ResistanceMolecular and Cellular Biology, 2004
- Unique and Conserved Features of Genome and Proteome of SARS-coronavirus, an Early Split-off From the Coronavirus Group 2 LineagePublished by Elsevier ,2003
- The Genome Sequence of the SARS-Associated CoronavirusScience, 2003
- Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory SyndromeScience, 2003
- Human Coronavirus 229E: Receptor Binding Domain and Neutralization by Soluble Receptor at 37°CJournal of Virology, 2003
- Identification of a Receptor-Binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229EJournal of Virology, 2003
- Cell line A549 as a model of the type II pneumocyteBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1979