Donor and Recipient Function 2 to 4 Years After Renal Homotransplantation

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Abstract
Paired studies in inulin clearance (GFR) [Glomular filtration rate] and p-aminohippurate [PAH] clearance (ERPF) [Effective renal plasma flow] were performed in 28 renal homograft recipients and their donors 21 to 48 months following transplantation. In 17 donors, endogenous creatinine (Ccr) and infusion PAH clearances had been obtained before nephrectomy. Donor GFR and ERPF averaged 75.5 ml/min. and 348 ml/min. respectively. In 17 patients, Ccr 3 years after uninephrectomy was 71.3[degree]/o and ERPF was 66.3[degree]/o of the preoperative values. A significant inverse correlation was demonstrated between age at the time of uninephrectomy and renal function 3 years later. Moreover, the ratio of postnephrec-tomy to prenephrectomy ERPF was significantly inversely correlated with age. Recipient GFR and ERPF averaged 65.8 ml/min. and 309 ml/min. respectively. Comparison of recipient with donor function indicated no significant difference in donor and recipient function an average of 34.4 months after operation. No correlation was found between recipient function and recipient or donor age. Disparity between donor and recipient function is discussed. There is impairment of the compensatory functional response to uninephrectomy with increasing age in healthy adults. Compensatory functional response of the transplanted kidney is equal to that of the remaining donor kidney.