Diphenylhydantoin and Calcium Movement in Lobster Nerves

1 October 1974

journal article
research article
Published by American Medical Association (AMA) in Archives of Neurology

Vol. 31 (4) , 250-254
https://doi.org/10.1001/archneur.1974.00490400064007

Abstract

Diphenylhydantoin reduces calcium Ca 45 uptake and outflow in resting lobster axons and eliminates the increase in⁴⁵Ca accumulation that normally occurs during stimulation. Hydroxyphenyl-phenylhydantoin was found to be without effect on resting or stimulated nerves with respect to⁴⁵Ca uptake. Procaine hydrochloride shared the same effects as diphenylhydantoin on resting nerves. It is hypothesized that a major mechanism of action of diphenylhydantoin is similar to that of local anesthetics.

Keywords

This publication has 10 references indexed in Scilit:

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