Antifertility Efficacy of Gossypol Acetic Acid in Male Rats

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Abstract
Fertility response and sperm motility of male Wistar rats exposed to various concentrations (2.5-30 mg/kg per day) of gossypol acetic acid (GAA) was studied. GAA was given orally. A marked reduction in fertility occurred when rats received > 15 mg/kg per day of GAA for 5-10 wk (P < 0.01); dosage < 15 mg had no antifertility effect even after 20 wk. There is some evidence that GAA administration (30 mg/kg) every other day for 10 wk had no antifertility effect. A clear relationship between the inhibition of sperm motility and GAA administration was observed (P < 0.01). The interrelationships between fertility, sperm motility and GAA treatment were analyzed by Yates'' chi-square test and Fisher''s exact test.