Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor
- 1 October 1981
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 58 (4) , 432-433
- https://doi.org/10.1007/bf00282831
Abstract
Fibroblasts of a patient with Bloom syndrome (GM-1492) were cultured in the presence of either mitomycin C, ethylmethanesulfonate, or 4-nitroquinoline-1-oxide, (4-NQ1-O) and sister chromatid exchange was determined. The mutagens enhanced the sister chromatid exchange rate to different degrees, 4-NQ1-O being the most potent substance. Bloom corrective factor, which is present in normal cell-conditioned culture medium, reduced the spontaneously increased SCE in Bloom syndrome cells by about 20 SCE per metaphase but failed to reduce the additional mutagen-induced SCE increase. These findings indicate that only spontaneously, but not mutagen-indeuced, SCE in Bloom syndrome fibroblasts can be decreased by the Bloom corrective factor.Keywords
This publication has 6 references indexed in Scilit:
- FUNCTIONAL DEFICIENCY OF FIBROBLASTS HETEROZYGOUS FOR BLOOM SYNDROME AS SPECIFIC MANIFESTATION OF THE PRIMARY DEFECT1981
- Rate of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by co-cultivation with normal fibroblasts.1980
- Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonateHuman Genetics, 1979
- Frequency of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by cocultivation with normal cellsHuman Genetics, 1979
- Effects of mitomycin C on sister chromatid exchange in normal and bloom's syndrome cellsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1978
- Sister chromatid exchanges induced by mutagenic carcinogens in normal and xeroderma pigmentosum cellsNature, 1977