SOME BIOLOGICAL PROPERTIES OF DIFFERENT ESTERS OF DESOXYCORTICOSTERONE

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Abstract
FOR many years the acetate of desoxycorticosterone (DCA) has occupied a preeminent position as the 11-desoxycorticoid of widest use. The compound is generally administered in oil solution and the effect of a single injection is of moderate duration. A quick-acting, water-soluble desoxycorticosterone—desoxycorticosterone glucoside—has been prepared; it is very effective in reviving dogs from crises of adrenal insufficiency (Meier, Gysel and Müller, 1944; Swingle, Perlmutt, Seay and Collins, 1952). We report here obervations on esters of desoxycorticosterone which, on the other hand, are markedly longer acting than DCA. It has been known for some time that esters of desoxycorticosterone other than its acetate had more prolonged activity and this was notably true of the benzoate and palmitate (Miescher, Fischer and Tschopp, 1938). More recently the trimethylacetate of desoxycorticosterone has been prepared by Wieland, Heer, Schmidlin and Miescher (1951). The preliminary results of these authors indicated a long duration of activity when this compound was given in oil solution to rats and dogs.