Somatic cell hybrids between totipotent mouse teratocarcinoma and rat hepatoma cells
- 1 October 1979
- journal article
- research article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 101 (1) , 1-8
- https://doi.org/10.1002/jcp.1041010102
Abstract
We have produced somatic cell hybrids between totipotent mouse teratocarcinoma cells and rat hepatoma cells. These hybrids were tested for the expression of liver specific functions expressed in the hepatoma cell parent and for their ability to differentiate when injected into nude mice. The results of this study indicate that hybrid cell clones do not resemble either of the parental cells, since they do not produce albumin and tyrosine aminotransferase that are expressed in the rat hepatoma parent, and are incapable of forming either teratocarcinoma or hepatomas when injected in experimental animals.This publication has 21 references indexed in Scilit:
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