Biochemical response to trauma. IV. Corticosteroid levels in plasma of rats subjected to tumbling trauma

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Abstract
The effect of tumbling trauma on the concentration of corticosterone (CS) and other corticosteroids (X-steroids) in the plasma of rats has been followed using a fluorimetric method for the analyses of the corticosteroid. Sprague-Dawley rats weighing 225–275 gm were used. The animals were tumbled for 300, 400, 500, 600 and 700 turns giving a 24-hour mortality ranging from 0 to 100%. The corticosterone levels immediately after the tumbling were increased 2–5 times while the X-steroid concentrations increased 5–10 times. When followed in time after tumbling, the corticosterone remained elevated for 1–2 hours and returned toward normal within 24 hours whereas the X-steroids rose to a peak about 1 hour and then fell to near zero between 1 and 2 hours after which a secondary rise occurs which rises about 8 hours and then returns toward normal within 24 hours.