THE EFFECT OF TESTOSTERONE PROPIONATE ON THE PROTEIN AND CARBOHYDRATE METABOLISM IN THE DEPANCREATIZED-CASTRATED DOG12

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Abstract
The administration of testosterone propionate at 25 to 100 mg./day for up to 56 days to partially regulated depancreatized-castrated dogs produced a constant increase in body weight accompanied by a retention of nitrogen and a decrease in glucose excretion. The nitrogen effect gradually “wore off” after 3 weeks of androgen injections but the effect on body weight and glucose excretion continued for the duration of treatment. Furthermore, on cessation of injections the nitrogen excretion increased but the glucose excretion gradually returned to the basal level. The blood glucose and NPN changed in parallel with the urinary constituents. The blood amino-N was not affected by androgen administration except for a short period of about 1 week at the end of maximum nitrogen retention and the beginning of the “wearing off” effect on the urinary nitrogen and the blood NPN.