THE EFFECT OF TESTOSTERONE PROPIONATE ON MUSCLE GLYCOGEN IN ALLOXAN DIABETIC RATS1

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Abstract
Studies were made on the changes in glycogen concentration in the rectus femoris, diaphragm and levator ani muscles of castrated rats, castrated rats treated with testosterone, intact diabetic, castrated-diabetic, and castrated-diabetic rats treated with testosterone. No change occurred in the glycogen concentration in the rectus femoris and diaphragm muscles of intact male rats made diabetic with alloxan, but the glycogen in the levator ani decreased. Castration decreased the glycogen concentration in these muscles but the imposition of diabetes on the castrated rats increased the glycogen in the rectus femoris and diaphragm muscle but not in the levator ani. Testosterone, which increased the glycogen in all 3 muscles in castrated rats, failed to increase the glycogen in the rectus femoris and diaphragm of the castrated-diabetic rats. In the levator ani, however, testosterone markedly increased the glycogen level. Growth response of the levator ani to testosterone was not influenced by the diabetic condition.