GLYCOGEN DEPOSITION IN DIFFERENT SKELETAL MUSCLES INDUCED BY CORTISONE AND ESTRADIOL1

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Abstract
Estradiol benzoate and cortisone acetate were injd. into normal, gonadectomized and hypophysectomized rats of both sexes to determine the effect on the glycogen levels in the following skeletal muscles: the rectus femoris, the abdominal muscles, the cremaster of the male, and the diaphragm of the female. In all expts., cortisone increased the glycogen content of the rectus femoris but failed to do so in the cremaster. The increase in muscle glycogen, induced by cortisone, varied quantitatively in the different muscles. Under similar conditions, more glycogene was deposited in the muscles of the female than in those of the male. Estradiol increased the storage of glycogen in all 3 muscles of the spayed female rats and only to a slight extent in the leg muscle of the castrated males. No increase in glycogen was observed in the muscles of the hypophysectomized rats treated with estradiol except for a small but statistically significant increase in the sensitive rectus femoris muscle of the female. Results emphasize that all skeletal muscles are not the same in their response of depositing glycogen under the influence of hormones.