EFFECT OF INSULIN ON THE TRANSFORMATION OF BALB/3T3 CELLS BY X-RAY-IRRADIATION
- 1 January 1983
- journal article
- research article
- Vol. 74 (6) , 864-869
Abstract
The effects of triiodothyronine (T3), hydrocortisone and insulin on X-ray-induced transformation of [mouse embryonic fibroblast] BALB/3T3 A31-1-1 cloned cells were examined. Under the experimental conditions employed, the addition of 10-7 M T3 or hydrocortisone to the serum-containing medium had little effect on the transformation. The addition of insulin dramatically enhanced the transformation. The effect of insulin was concentration-dependent up to 10 .mu.g/ml and was consistently observed with X-rays at various doses.This publication has 13 references indexed in Scilit:
- Reversal of the promotional effect of 12-O-tetradecanoylphorbol-13-acetate on morphological transformation of hamster embryo cells by glucocorticoidsCancer Letters, 1982
- ENHANCED TRANSFORMATION OF MOUSE 10T1/2 CELLS BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE FOLLOWING EXPOSURE TO X-RAYS OR TO FISSION-SPECTRUM NEUTRONS1982
- Crucial role of thyroid hormone in x-ray-induced neoplastic transformation in cell culture.Proceedings of the National Academy of Sciences, 1981
- Epidermal growth factor, like tumor promoters, enhances viral and radiation-induced cell transformationCarcinogenesis: Integrative Cancer Research, 1981
- RADIATION-INDUCED TRANSFORMATION OF 10T1/2 MOUSE CELLS IN THE PLATEAU PHASE - POST-IRRADIATION CHANGES AND SERUM DEPENDENCE1981
- Effects of 17β-estradiol on radiation transformation in vitro; inhibition of effects by protease inhibitorsCarcinogenesis: Integrative Cancer Research, 1981
- Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.Proceedings of the National Academy of Sciences, 1980
- Thyroid hormone modulation of X ray-induced in vitro neoplastic transformationNature, 1980
- EFFECT OF TIME AND DURATION OF EXPOSURE TO 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON X-RAY TRANSFORMATION OF C3H 10T1/2 CELLS1980
- QUANTITATIVE STUDIES OF RADIATION TRANSFORMATION WITH THE A31-11 MOUSE BALB-3T3 CELL-LINE1979