The role of sulfated mucopolysaccharides in cleft palate production

Publisher Website
Google Scholar
Abstract
Offspring of rats treated with vitamin A, cortisone, or both drugs were studied with the aid of 35S‐sulfate to investigate whether sulfated‐mucopolysaccharides have a role in cleft palate production. Vitamin A alone or combined with cortisone produced a high frequency of cleft palate. Cortisone alone produced no cleft palates. Autoradiographic results showed that 35S‐sulfate incorporation in palatal tissue of control fetuses and those from rats treated with both drugs was almost similar, whereas isotope incorporation was several times higher than this in the vitamin A‐treated group and slightly less than this in the cortisone‐treated group. The results appear to indicate that there is no relation between disturbed sulfate mucopolysaccharide metabolism and the production of cleft palate.
Keywords