Biological properties of the gastric juice inhibitory substance produced by Streptomyces bottropensis F4708.

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Abstract
Gastric juice inhibitory substance (GIS) produced by Streptomyces bottropensis F4708 suppressed carrageenin-induced edema but did not show analgesic effect or influence the circulation system. Effect of adrenergic antagonists on the gastric juice inhibition and lowering of body temperature by GIS was examined. The gastric juice inhibitory activity of GIS was not affected by premedication with Dibenamine or Propranolol. However, the lowering of body temperature by GIS was markedly reinforced by premedication with the antagonists. The dark brown pigment component from GIS was presumed to be a melanin-like substance by comparing its chemical properties with those of DOPA-melanin which exhibited a significant reduction of gastric secretion in rats. Therefore, the gastric juice inhibitory activity of GIS was found to depend on this pigment component in its molecule. Lowering of body temperature of rats was not observed by the administration of DOPA-melanin.