A model system for analyzing somatic mutations in Drosophila melanogaster
- 15 April 2007
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 4 (5) , 401-403
- https://doi.org/10.1038/nmeth1027
Abstract
Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two-to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.This publication has 10 references indexed in Scilit:
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