EFFECT OF DI-ETHYL ETHER ANESTHESIA ON THYROID FUNCTION OF RATS

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Abstract
The mechanism of the action of ether anesthesia on thyroid function was studied. Ether anesthesia did not significantly influence the following: (1) radio-active iodine (I131) absorption from the peritoneal cavity, (2) gastrointestinal tract or urinary excretion of I131, (3) serum concentration of I131, or (4) T/S ratio. The uptake and secretion of radioiodine by rat thyroid was significantly inhibited by administration of ether anesthesia. Thiopental, however, if any-thing, increased the release of radioiodine from the thyroid. Pcntobarbital (Nembutal) had no effect. Radioactive protein-bound iodine (PBI131) of the rat thyroid was signifi-cantly less in the ether anesthetized groups than in the control animals. Paper chromatographic study of the thyroid showed that in the ether anesthetized groups, in contrast with the control rats, the content of thja-oxine plus tri-iodothyronine was markedly reduced compared to the reduction in the content of moniodotyrosine plus diiodotyrosine.