THE EFFECT OF DRUGS ON THE EXCRETION OF THEILER'S VIRUS (TO) BY MICE1

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Abstract
1. A method for assay of effects of drugs on the excretion of Theiler 's virus (TO) by mice is described. 2. Comparison of excretion of virus in 110 untreated mice at 3 to 4 weeks of age and 1 week later indicates that in 55 per cent the concentration of virus remains unchanged or increases, while in 45 per cent there is a decrease. 3. Variations in food and water intake do not influence the amount of virus excreted. 4. Of 106 chemicals tested, only certain mercurial compounds produce consistent reduction in the amount of Theil-er's virus excreted. 5. Mercuric alpha-mercapto-p-(2-thi-azolylsulfamyl) acetanilide, mono sodium salt (MC-858) and mercuric alpha-mercapto-p-sulfamylacetanilide (MC—2308) appeared to be the most effective and least toxic of the mercurial compounds tested. 6. At drug-diet dosage levels greater than 2 per cent, MC—858 and MC—2308 reduced the excretion of Theiler's virus to undetectable amounts in 46 per cent of 37 mice. 7. Discontinuance of the drug was followed by reappearance of virus in the feces in approximately one half the animals by the seventh day. 8. On the basis of the concentration of mercury in the feces, MC—858 and MC—2308 exerted much greater effects in vivo than in vitro.

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