Mapping of Simian Virus 40 Early Functions on the Viral Chromosome
- 1 September 1973
- journal article
- research article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 12 (3) , 653-658
- https://doi.org/10.1128/jvi.12.3.653-658.1973
Abstract
The simian virus 40 (SV40) DNA segment in the nondefective adenovirus 2-SV40 hybrid, Ad2 + ND 4 , is colinear with the segment between 0.11 and 0.59 SV40 fractional length from the site at which the R 1 restriction endonuclease cleaves SV40 DNA. This specifies the region of the SV40 DNA molecule which induces the early SV40 antigens: U antigen, tumor specific transplantation antigen, and T antigen. A variant of Ad2 + ND 4 , called Ad2 + ND 4del , was found which has a deletion of the DNA segment between 0.50 and 0.57 SV40 fractional length from the R 1 endonuclease cleavage point.Keywords
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