ACTION OF SOME SYNTHETIC STEROIDS IN ADRENALECTOMIZED IMMATURE RAT

Abstract
Pregnenin-17-ol-3-one in daily dosages of 5 or 10 mg. per os failed to increase the survival time of adrenalectomized, immature [male] rats. [DELTA] 5-pregnene-3-ol-20-one in amts..up to 2 mg./day parenterally in sesame oil failed to prolong life in adrenalectomized, immature, [male] rats. [DELTA] 8-pregnene-3-ol-20-one-21-ol-acetate was markedly potent and fell between progesterone and desoxycorticosterone acetate in its ability to produce growth and to lengthen the survival time of adrenalectomized, immature, [male] rats.