Tourniquet Shock in Mice

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Abstract
The rate of Na and protein turnover in the fluid accumulated in the area of injury following treatment of mice previously injured by tourniquet trauma was estimated by administering tracer doses of Na22Cl and S35-plasma after maximal swelling had occurred, and measuring the time required for equilibrium. Na22 equilibrated in 1-2 hours. Labeled protein, in contrast to results with prelabeling, equilibrated only 30% in 2 hours; 55% in 6 hours, and 80% in 15 hours. The fluid accumulated in the injured area after swelling is complete behaves as a stagnant pool with respect to the exchange of protein.