Effect of attenuated cells on the growth of small implant of yoshida ascites hepatoma AH109A.

Publisher Website
Google Scholar
Abstract
The transplantability of small implants such as 10 cells of Yoshida ascites hepatoma AH109A, which grew lethally in only 2 out of 19 rats when transplanted s.c., was improved by admixed implantation of attenuated tumor cells prepared with mitomycin C, presenting lethal take in 23 out of 27 animals. Similar effect was also obtained by liver homogenate or sonicated tumor cell suspension. Although the rate of tumor take of less than 103 cells of AH109A inoculated in the subcutis increased by admixing the attenuated cells, growth characteristics of such a small tumor implant, once initiated, were not significantly different whether inoculated with or without the attenuated cells. Growth support effect of attenuated cells was discussed in relation with the inoculum size or growth ability of tumor cells.