Investigation of Prostaglandins for Abortion

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Abstract
Intravaginal administration of 15-ME-PGF2.alpha. methyl ester is at present the closest to an ideal abortifacient. It possesses relative ease of administration, reversibility, high success rate with acceptable abortion time, minimal side effects, it is non-operative and without sequelae. The major disadvantage of this technique appears to be that the prostaglandin absorption from the vagina can be significantly impaired either by vaginal bleeding or by variable release of prostaglandin from the device itself. This variable absorption rate has resulted in a variable success rate. Development of a more efficient delivery system for this effective agent may provide a method which is superior to anything currently available.