LINKED GENES ARISING AMONG MULTIPLE MUTANTS IN EMS-TREATED SACCHAROMYCES

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Abstract
Previous work has established that EMS treatment of Saccharomyces yields a relatively efficient method for harvesting viable biochemical mutants, and that cells bearing multiple biochemical deficiencies occur with unusually high frequency. In addition a genetic analysis of these multiple mutations has shown a non-random "clustering" of these multiple mutations relative to the total chromosome map.Apparently for reasons which are not immediately clear, EMS-treatment produces an unexpectedly rich abundance of multiple mutations among genetically linked loci. Conceivably, this could occur if only specific chromosomal regions were "open" to the mutagenic action of EMS at any given time.

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