Helicobacter pylori phase variation, immune modulation and gastric autoimmunity
- 1 February 2006
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 4 (2) , 151-159
- https://doi.org/10.1038/nrmicro1344
Abstract
Helicobacter pylori can be regarded as a model pathogen for studying persistent colonization of humans. Phase-variable expression of Lewis blood-group antigens by H. pylori allows this microorganism to modulate the host T-helper-1-cell versus T-helper-2-cell response. We describe a model in which interactions between host lectins and pathogen carbohydrates facilitate asymptomatic persistence of H. pylori. This delicate balance, favourable for both the pathogen and the host, could lead to gastric autoimmunity in genetically susceptible individuals.Keywords
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