Studies on basidiomycetes. I. Antitumor polysaccharide from bagasse medium on which mycelia of Lentinus edodes (Berk.) Sing. had been grown.

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Abstract
From bagasse medium on which mycelia of L. edodes was grown, an acidic polysaccharide (fraction C-1-2) was isolated by deproteinization, removal of nucleic acid, fractionation with barium hydroxide and DEAE-cellulose column chromatography. The purified polysaccharide consisted mainly of xylose, arabinose, mannose, galactose, glucose and uronic acid in a M ratio of 1.4:0.7:2.0:0.9:1.0:1.5. The tumor inhibition ratio of the polysaccharide against solid sarcoma 180 was 87.9% in mice given doses of 100 mg/kg .times. 10 days by i.p. administration; the tumors in 5 of 10 mice completely regressed.