Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?
Top Cited Papers
- 1 July 2005
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 94 (7) , 1427-1444
- https://doi.org/10.1002/jps.20364
Abstract
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This publication has 35 references indexed in Scilit:
- Steady-State Tryptophan Fluorescence Spectroscopy Study to Probe Tertiary Structure of Proteins in Solid PowdersJournal of Pharmaceutical Sciences, 2003
- Dynamics of Pharmaceutical Amorphous Solids: The Study of Enthalpy Relaxation by Isothermal MicrocalorimetryJournal of Pharmaceutical Sciences, 2002
- Solid‐state chemical stability of proteins and peptidesJournal of Pharmaceutical Sciences, 1999
- Effect of Excipients on the Stability and Structure of Lyophilized Recombinant Human Growth HormoneJournal of Pharmaceutical Sciences, 1998
- Determining the Water Sorption Monolayer of Lyophilized Pharmaceutical ProteinsJournal of Pharmaceutical Sciences, 1997
- Quantitation of the Area of Overlap between Second-Derivative Amide I Infrared Spectra To Determine the Structural Similarity of a Protein in Different StatesJournal of Pharmaceutical Sciences, 1996
- Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized formBiochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1995
- Heat capacity of hydrated and dehydrated globular proteins. Denaturation increment of heat capacityFood Hydrocolloids, 1993
- Cold Denaturation of ProteinCritical Reviews in Biochemistry and Molecular Biology, 1990
- An infrared spectroscopic study of the interactions of carbohydrates with dried proteinsBiochemistry, 1989