THE EFFECT OF METHYLTHIOURACIL ON THE OXYGEN CONSUMPTION OF THE THYROID, LIVER AND KIDNEYS
- 1 June 1948
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 42 (6) , 427-435
- https://doi.org/10.1210/endo-42-6-427
Abstract
The effect of methylthiouracil on O2 con-sumption of thyroid, liver and kidney was studied. Thyroidec-tomized animals were also investigated. O2 consumption of the thyroid increased rapidly after drug admn. probably due to follicle growth. The livers from thyroidectomized animals treated with methylthiouracil show a lower O2 consumption than do those of the control animals. The O2 consumption of the liver and kidney falls relatively soon after methylthiouracil treatment is begun. The cause of this appears to be a decreased synthesis of thyroid hormone. Further, there is a clear[long dash]at least as far as the liver is concerned[long dash]direct effect of methylthiouracil.Keywords
This publication has 17 references indexed in Scilit:
- EFFECT OF THIOURACIL ON THE IODINE CONTENT OF THE THYROID GLAND1Endocrinology, 1944
- THE EFFECT OF THIOURACIL ON THE FORMATION OF THYROXINE AND DIIODOTYROSINE BY THE THYROID GLAND OF THE RAT WITH RADIOACTIVE IODINE AS INDICATOR1Endocrinology, 1944
- THE UPTAKE OF RADIOACTIVE IODINE BY THE THYROIDS OF RATS MADE GOITEROUS BY POTASSIUM THIOCYANATE AND BY THIOURACIL1Endocrinology, 1944
- MODE OF ACTION OF THIOUREA ON THE THYROID GLAND OF RABBITSEndocrinology, 1944
- FLUORESCENT AND HISTOCHEMICAL REACTIONS IN THE RAT THYROID GLAND AT DIFFERENT STATES OF PHYSIOLOGICAL ACTIVITY11,Endocrinology, 1944
- TREATMENT OF HYPERTHYROIDISM WITH THIOUREA AND THIOURACILJAMA, 1943
- ACTION OF CERTAIN SULFONAMIDES AND OF THIOUREA UPON THE FUNCTION OF THE THYROID GLAND OF THE RAT1Endocrinology, 1943
- EFFECT OF SULFONAMIDES AND THIOUREAS ON THE THYROID GLAND AND BASAL METABOLISM12Endocrinology, 1943
- Thio-Ureas as Goitrogenic SubstancesNature, 1942
- STUDIES ON THE THYROTROPIC HORMONE OF THE ANTERIOR PITUITARYJAMA, 1935