Brain Uptake of Carbamazepine in the Cat

Publisher Website
Google Scholar
Abstract
Carbamazepine (CBZ) was determined by EMIT [enzyme multiplied immunoassay technique] assay in plasma, CSF and brain samples of cats after administration of the drug (40 mg/kg, i.p.). Plasma and CSF levels increase in a parallel manner from time 0-90 min after completion of injection, indicating a passive transport from 1 body fluid to the other. Brain levels reach a steady state at 15 min, with no significant difference being found between the concentrations of 15, 30, 60 and 90 min postinjection; this indicates that substantial early binding occurs in the brain. Since peak CSF concentrations occur at 90 min, concomitant with those for plasma, while brain levels are already high at 15 min, it is likely that CBZ enters the 2 compartments by independent mechanisms.