THE EFFECT OF ANTERIOR HYPOTHALAMIC LESIONS ON THYROID FUNCTION AND GOITER DEVELOPMENT IN THE RAT1

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Abstract
Thyroid function was measured in rats lesioned in the anterior hypothalamus, using the 24-hour radioiodine uptake test, the hormone discharge rate both on a control diet and during the administration of propylthiouracil, the T/S ratio test of VanderLaan, the PBI and the serum cholesterol level. The results of all tests with the exception of the T/S ratio indicate an interference with hypophyseal thyrotropin production in lesioned animals, with lesions which block the hypertrophy response of the thyroid to goitrogens being most effective in reducing thyrotropin production. Assays of pituitary thyrotropin content paralleled the thyroid function data. These experiments are interpreted as arguing against the existence of two distinct thyrotropins in the rat.