Experimental murine amyloidosis: Experience with Candida albicans as an amyloidogenic agent and liver biopsy as a diagnostic tool

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Abstract
A method of inducing experimental amyloidosis in mice using Candida albicans injections is described. Viable and non-viable Candida produced amyloid and results with each method were compared. Diagnosis was by liver biopsy, a technique of value in assessing natural history of the disease. Once the amyloid was induced, the disease always progressed until the animals died of generalized amyloidosis. This experimental model should be suitable to use in assessing amyloidosis treatment.